Prospective study to compare the dose distribution and acute toxicity of three-dimentional conformal radiation therapy with intensity-modulated radiation therapy for post-mastectomy radiotherapy in carcinoma breast

Though adjuvant radiotherapy has an established role in the treatment of carcinoma breast, there is concern regarding irradiation to heart and lung, more on left sided disease. Intensity Modulated Radiation Therapy (IMRT) modulates intensity radiation beams with better accuracy, sparing surrounding normal organs. But it increases integral dose healthy tissues compared 3-Dimensional Conformal (3DCRT). So, our study was aimed at comparing dosimetry acute toxicity profile 3DCRT IMRT post-mastectomy patients. In arm patients received control 3DCRT, being 50 Gy 25 fractions for 5 weeks both arms. We dosimetric data Planning Target Volume (PTV) Organ At-risk (OAR) by techniques along profile. Dosimetric parameter PTV coverage V95 V107 were significantly than (p-value <0.0001). showed homogeneity index (0.14 vs 0.26 Gy) conformity also (0.94 0.74 Gy, p-value 0.0028). The mean value V25 disease lower (22.59 25.64, p 0.01). V20 ipsilateral lung numerically less though not significant (31.44 35.3). low volume IMRT, as seen higher V5 lung. To conclude, organs risk homogenous conformal plans 3DCRT. Keywords: radiotherapy; IMRT; 3DCRT; breast